An isotype is a class of antibody, determined by the heavy-chain constant region. There are the following isotypes in animal serum, including rabbits:
  • IgA - Immunoglobulin A is found mainly in mucosal secretions such as: saliva, tears, colostrum, mucus and blood. IgA is involved in neutralization of pathogens by enabling their attachment to mucosal surfaces.
  • IgE - immunoglobulin E is involved in allergic response.
  • IgD - immunoglobulin D is present in very low concentrations in blood and is mainly found on the surface of mature B cells.
  • IgG - immunoglobulin G is the most abundant antibody type, comprising from 75 to 80 % of total immunoglobulin pool with a concentration between 10 - 20 mg/ml.
  • IgM - immunoglobulin M is produced during first stages of immunological response to antigen, and it is the largest antibody, which is efficient in agglutination clumping) of antigens.
Rabbits have four immunoglobulin types: IgA, IgG, IgM and IgE. Except IgA, each immunoglobulin type has only one subtype, while IgA has 14 subtypes. Produced polyclonal, rabbit antibody is most likely IgG type. IgM immunoglobulin is induced by first immunization, as a part of primary immunoglogical response followed by class switching and secondary response, where IgG is prominent.

  
Antibody molecule


 

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